The beekeepers in India and Nepal apply formic acid or sulfur powder to control parasitic mites in Apis mellifera colonies. The ectoparasitic mites, V. jacobsoni and T. clareae create difficulties in keeping A. mellifera. Fifty A. mellifera colonies of similar size were randomly selected and grouped into 6 experimental groups. We used formic acid (group I) sulfur powder (group II), apistol (Chinese stripes containing Klartane-group III), bayvarol (group IV), perizin (group V) and a biological method invented by Woyke (1987a, b, c) (group VI). The colonies in each group were treated for 5 weeks. After final treatment, we found 0-429 T. clareae on the bottom insert in particular colonies. The highest average efficiency was found in colonies treated with Apistol (97.9 %) and the lowest with sulfur powder (57.3 %).